San Francisco's pass rush continues to be among the best in the NFL, owning the sixth-highest pressure rater thus far. This feels like it could be a 49ers bludgeoning on Thursday night. This initially opened at 49ers -9.5 but ticked up the half point to get to 10 coming out of Week 2 and has flirted with 10.5 at certain books.

49ers: WR Brandon Aiyuk (shoulder), CB Ambry Thomas (knee) QUESTIONABLE.Giants: RB Saquon Barkley (ankle), OL Andrew Thomas (hamstring), OL Ben Bredeson (concussion), LB Azeez Ojulari (hamstring) OUT WR Wan'Dale Robinson (knee), LB Micah McFadden (neck) QUESTIONABLE.Location: Lincoln Financial Field (Philadelphia) Before we do, let's make sure you know how to watch this prime-time head-to-head.Īll NFL odds are via Caesars Sportsbook. We'll look at the line movement leading up to Thursday, the total, and dive into a handful of player props. Here, we're going to take a look at this game from a gambling perspective. Meanwhile, the Niners are one of the handful of teams that have started out the season 2-0, but of those victories have come on the road as they head into the home opener.

Brian Daboll's team stayed on the West Coast this week after taking on the Arizona Cardinals, a game where they needed to rally from a 20-0 halftime deficit to earn their first win of the year. Week 3 in the NFL kicks off from Levi's Stadium where the the San Francisco 49ers will host the New York Giants on Thursday night.

How to bet on football game spread